Detailed view for OVOC5897

Basic information

TDR Targets ID: 994030
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 3.2817 | Length (AA): 718 | MW (Da): 75478 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02826  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
290 603 4lsw (A) 2 314 20.00 0 1 0.666165 -0.19
319 593 2g76 (A) 35 305 37.00 0 1 0.831984 -0.44
322 781 1ygy (A) 36 492 26.00 0 1 0.851276 0.4
430 495 6aqj (A) 15 81 29.00 0.055 1 0.532428 -0.78
430 522 5v96 (A) 252 341 21.00 0.0085 0.98 0.456476 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127006)

Species Accession Gene Product
Arabidopsis thaliana AT1G17745   D-3-phosphoglycerate dehydrogenase
Arabidopsis thaliana AT4G34200   D-3-phosphoglycerate dehydrogenase
Arabidopsis thaliana AT3G19480   D-3-phosphoglycerate dehydrogenase
Brugia malayi Bm1_57055   D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain containing protein
Candida albicans CaO19.12728   similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase
Candida albicans CaO19.5263   similar to S. cerevisiae SER3 (YER081W) 3-phosphoglycerate dehydrogenase
Caenorhabditis elegans CELE_C31C9.2   Protein C31C9.2
Dictyostelium discoideum DDB_G0281071   3-phosphoglycerate dehydrogenase
Drosophila melanogaster Dmel_CG6287   CG6287 gene product from transcript CG6287-RA
Escherichia coli b2913   D-3-phosphoglycerate dehydrogenase
Entamoeba histolytica EHI_060860   D-3-phosphoglycerate dehydrogenase, putative
Homo sapiens ENSG00000092621   phosphoglycerate dehydrogenase
Leishmania braziliensis LbrM.03.0050   D-3-phosphoglycerate dehydrogenase-like protein
Leishmania donovani LdBPK_030030.1   D-3-phosphoglycerate dehydrogenase-like protein
Leishmania infantum LinJ.03.0030   D-3-phosphoglycerate dehydrogenase-like protein
Leishmania major LmjF.03.0030   D-3-phosphoglycerate dehydrogenase-like protein
Leishmania mexicana LmxM.03.0030   D-3-phosphoglycerate dehydrogenase-like protein
Loa Loa (eye worm) LOAG_05547   hypothetical protein
Mycobacterium leprae ML1692c   PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH)
Mus musculus ENSMUSG00000053398   3-phosphoglycerate dehydrogenase
Mycobacterium tuberculosis Rv2996c   Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH)
Mycobacterium ulcerans MUL_1952   D-3-phosphoglycerate dehydrogenase
Neospora caninum NCLIV_016450   hypothetical protein
Oryza sativa 4337230   Os04g0650800
Oryza sativa 4341713   Os06g0655100
Oryza sativa 4345710   Os08g0447000
Onchocerca volvulus OVOC5897  
Saccharomyces cerevisiae YIL074C   phosphoglycerate dehydrogenase SER33
Saccharomyces cerevisiae YER081W   phosphoglycerate dehydrogenase SER3
Schistosoma japonicum Sjp_0016670   ko:K00058 D-3-phosphoglycerate dehydrogenase [EC1.1.1.95], putative
Schmidtea mediterranea mk4.065236.01   D-3-phosphoglycerate dehydrogenase
Schmidtea mediterranea mk4.000146.05   D-3-phosphoglycerate dehydrogenase
Toxoplasma gondii TGME49_239820   D-3-phosphoglycerate dehydrogenase
Trichomonas vaginalis TVAG_432360   2-hydroxyacid dehydrogenase, putative
Trichomonas vaginalis TVAG_462360   2-hydroxyacid dehydrogenase, putative
Trichomonas vaginalis TVAG_154750   D-3-phosphoglycerate dehydrogenase, putative

Essentiality

OVOC5897 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2913 Escherichia coli non-essential goodall
CELE_C31C9.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C31C9.2 Caenorhabditis elegans slow growth wormbase
TGME49_239820 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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